Description: Src Inhibitor 1 (Src Kinase Inhibitor 1) is a potent and selective dual site Src tyrosine kinase inhibitor. Target: Src. Smiles: N(C=1C2=C(C=C(OC)C(OC)=C2)N=CN1)C3=CC=C(OC4=CC=CC=C4)C=C3. References: Tian G, et al. Structural determinants for potent, selective dual site inhibition of human pp60c-src by...

The Src kinases constitute a family of non-receptor tyrosine kinases, which includes Src and Lck. Src kinase inhibitor I is a potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes. It less effectively blocks the receptor tyrosine kinases VEGFR2 and C-fms (IC50 =...