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Item number: Cay21054-10

PF-06651600 is a covalent inhibitor of JAK3 (IC50 = 33.1 nM). It is selective for JAK3 over JAK1, JAK2, and tyrosine kinase 2 (TYK2, IC50s = >10,000 for all) and a panel of 304 other kinases at 1 µM. PF-06651600 inhibits STAT5, STAT6, and STAT3 phosphorylation induced by IL-2, IL-4, or IL-21, respectively, in...

Keywords:	Ritlecitinib, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one
Application:	Covalent JAK3 inhibitor
CAS	1792180-81-4
MW:	285.3 D

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