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Item number: TGM-T16680-100mg

Description: PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspase-mediated apoptosis. Target: Apoptosis, BMI-1. Smiles:...

Application:	BMI1 inhibitor
CAS	1782970-28-8
MW:	405.32 D

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PTC-028

Item number: Cay34471-1

PTC-028 is an inhibitor of B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), which is a member of the polycomb repressive complex 1 (PRC1) that has a role in gene silencing. It inhibits proliferation of OVCAR-4 and OV-90 ovarian cancer cells (IC50s = ~0.1 µM for both). It also induces BMI1...

Keywords:	6-(5,6-difluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrazinamine
Application:	BMI1 inhibitor
CAS	1782970-28-8
MW:	405.3 D

From 61.00€ *

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