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Item number: Cay29188-1

CP 376,395 is an antagonist of corticotropin-releasing factor (CRF) receptor 1 (CRF1, IC50 = 5.1 nM). It inhibits adenylate cyclase activity stimulated by ovine CRF in rat cerebral cortex and at human CRF1 receptors. CP 376,395 (17.8 mg/kg) inhibits CRF-induced increases in the acoustic startle response in rats. It...

Keywords:	CP 316311, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine
Application:	Corticotropin-releasing factor receptor 1 (CRFR-1) antagonist
CAS	175140-00-8
MW:	326.5 D

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