Description: m-Carboxycinnamic acid bishydroxamide, an effective HDAC inhibitor, shows ID50 values of 10 nM for HDAC1 and 70 nM for HDAC3 in vitro, demonstrating its potent activity. Additionally, it promotes apoptosis and inhibits tumor growth, highlighting its therapeutic potential [1][2]. Target: Others. Smiles:...

Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. Importantly, HDAC inhibitors induce apoptosis in some cancer cells and show promise in the treatment of certain forms of cancer. CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 0.01 and...