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Item number: TGM-T3643-100mg

Description: HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1). Target: PLK. Smiles: COc1ccc(cc1)S(=O)(=O)Nc1ccccc1\C=C\c1cc[n+]([O-])cc1. References: DiMaio MA, et al. The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by...

Application:	Anticancer agent, active HMN-214 metabolite
CAS	173529-10-7
MW:	382.43 D

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HMN-176

Item number: Cay37424-10

HMN-176 is an anticancer agent and active metabolite of the prodrug HMN-214 (Cay-26210). It is cytotoxic against a panel of cancer cell lines with a mean IC50 value of 112 nM, as well as P388 leukemia cells that are resistant to the DNA-crosslinking agent cisplatin (Cay-13119), anthracycline antitumor antibiotic...

Keywords:	4-methoxy-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-benzenesulfonamide
Application:	Anticancer agent, active HMN-214 metabolite
CAS	173529-10-7
MW:	382.4 D

From 122.00€ *

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