Description: PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively. Target: Src, EGFR, Bcr-Abl, Apoptosis, c-Kit. Smiles: NC1=C2C(=NN(C(C)(C)C)C2=NC=N1)C3=CC=C(C)C=C3. References: Hanke JH, et al. J Biol Chem, 1996, 271(2), 695-701.

PP1 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM), and Src (IC50 = 170 nM) without significantly affecting the activity of EGFR kinase (IC50 = 250 nM), JAK2 (IC50 = 50 µM),...

Highly potent and selective Scr family tyrosine kinase inhibitor. Shows anti-Ras cancer potential by blocking Ras-induced activation of PAK1. Antitumor compound. RIP2 inhibitor. Blocks TGF-beta-mediated cellular responses.

A highly potent and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase. Melting Point: 190-192°C, Solubility: Chloroform, Ethyl Acetate, Method for Determining Identity: Proton NMR (CDCl3) Spectroscopic and Mass Spectrometric Analysis, TLC Conditions: SiO2:...

Src inhibitor.