Description: E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG. Target: GluR. Smiles: CCC(N)(C(O)=O)c1ccc(cc1)C(O)=O. References: Sekiyama N et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptorsubtypes....

E4CPG is an antagonist of metabotropic glutamate receptor 1 (mGluR1) and mGluR2. It is selective for mGluR1 and mGluR2 over mGluR6 at 1 mM. E4CPG (1 mM) inhibits L-glutamate-induced increases in inositol phosphate (InsP) levels in CHO cells expressing mGluR1 and prevents forskolin-induced decreases in cAMP levels in...