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PF-543 hydrochloride
Item number: TGM-T8840-100mg
Description: PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Target: Autophagy, S1P Receptor, Apoptosis, LPL Receptor. Smiles: Cl.Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1....
| Keywords: | PF-543 |
| Application: | Sphingosine kinase 1 inhibitor |
| CAS | 1706522-79-3 |
| MW: | 502.1 D |
From 33.00€
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PF-543 (hydrochloride)
Item number: Cay17034-5
PF-543 is a potent inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 2 nM) that inhibits sphingosine-1-phosphate (S1P) binding to human recombinant SPHK1 (Ki = 3.6 nM). It is selective for SPHK1 over SPHK2 (IC50 = 356 nM) as well as a panel of protein and lipid kinases and S1P receptors at a concentration of 10 µM....
| Keywords: | 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2R-pyrrolidinemethanol, monohydrochloride |
| Application: | Sphingosine kinase 1 inhibitor |
| CAS | 1706522-79-3 |
| MW: | 502.1 D |
From 43.00€
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