Description: Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC), competitively and reversibly inhibits PKCbetaI and PKCbetaII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCbeta over other PKC isozymes (IC50values are 0.052, 0.25, 0.30,...

LY333531 is an inhibitor of PKCbeta (IC50s = 4.7 and 5.9 nM for PKCbeta1 and PKCbeta2, respectively). It is selective for PKCbeta1 and PKCbeta2 over PKCalpha, -gamma, -delta, -epsilon, -zeta, and -eta (IC50s = 360, 300, 250, >100,000, and 52 nM, respectively). LY333531 also inhibits glycogen synthase kinase 3beta...

Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta) - PKCbeta-I and PKCbeta-II isozyme inhibitor - Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy - Anti-cancer and anti-angiogenic compound - Suppresses glucose-induced adhesion of human monocytes to endothelial...