Description: Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM. Target: NAMPT, c-Fms, CSF-1R. Smiles: CC(C)(O)CS(=O)(=O)NC1=CC2=C(CN(CC2)C(=O)COC2=CC=CN=C2)C=C1. References: Zhao G, et al. Discovery of a Highly Selective NAMPT...

Nampt-IN-1 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt, IC50 = 3.1 nM). It is selective for Nampt over a panel of greater than 100 human kinases at 1 µM. Nampt-IN-1 inhibits NAD+ formation in and proliferation of HCT116 cells (IC50s = 1.8 and 8.9 nM, respectively). It inhibits cell growth...