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Item number: TGM-T16798-1mL

Description: RS 17053 hydrochloride is a potent and selective antagonist of the alpha1A adrenoceptor, with a pKi value of 9.1 in native cell membranes and a pA2 value of 9.8 in functional assays. Target: Adrenergic Receptor, Others. Smiles: Cl.CC(C)(Cc1c[nH]c2ccc(Cl)cc12)NCCOc1ccccc1OCC1CC1. References: Ford AP, et...

Keywords:	RS-17053
Application:	alpha1A-adrenergic receptor antagonist
CAS	169505-93-5
MW:	449.41 D

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RS 17053 (hydrochloride)

Item number: Cay33548-10

RS 17053 is an alpha1A-adrenergic receptor (alpha1A-AR) antagonist. It selectively binds to the alpha1A-AR (Ki = 2.5 nM) over alpha1B- and alpha1D-ARs (Kis = 50 and 79 nM, respectively). RS 17053 inhibits norepinephrine-induced contractions in isolated rat kidney and mesenteric arteries (pA2s = 9.8 and 9.9,...

Keywords:	5-chloro-N-[2-[2-(cyclopropylmethoxy)phenoxy]ethyl]-alpha,alpha-dimethyl-1H-indole-3-ethanamine, monohydrochloride
Application:	alpha1A-adrenergic receptor antagonist
CAS	169505-93-5
MW:	449.4 D

From 147.00€ *

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