Description: BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor...

PD-1/PD-L1 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1). It inhibits the PD-1/PD-L1 interaction in a time-resolved FRET (TR-FRET) assay (IC50 = 6-100 nM). PD-1/PD-L1 inhibitor 1 reduces LPS-induced increases in PD-1 levels and apoptosis in...