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Item number: TGM-T2753-100mg

Description: Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 µM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenzymes CYP2C9/1A2/2C19 (IC50: 2.9/13.9/26.5 µM). Target: Acyltransferase, P450....

Keywords:	CI-1011, PD-148515
Application:	Targets sterol O-acyltransferase [EC:2.3.1.26] (SOAT)
CAS	166518-60-1
MW:	501.72 D

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Avasimibe

Item number: Cay18129-10

Acyl-Coenzyme A:cholesterol acyltransferases (ACAT1 and ACAT2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. Avasimibe is an orally bioavailable inhibitor of ACAT (IC50s = 24 and 9.2 µM for ACAT1 and...

Keywords:	Cl-1011, PD-148515, 2,6-bis(1-methylethyl)phenyl ester N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-sulfamic acid
Application:	ACAT inhibitor
CAS	166518-60-1
MW:	501.7 D

From 66.00€ *

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