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AZ6102
Item number: TGM-T6768-100mg
Description: AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. Target: PARP, Wnt/beta-catenin. Smiles: C[C@H]1CN(C[C@@H](C)N1)c1cc(C)c(cn1)-c1ccc(cc1)-c1nc2n(C)ccc2c(=O)[nH]1. References: Johannes...
| Application: | TNKS1/2 inhibitor |
| CAS | 1645286-75-4 |
| MW: | 428.53 D |
From 38.00€
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AZ 6102
Item number: Cay19898-1
AZ 6102 is an inhibitor of tankyrases (TNKS) 1 and 2 with IC50 values of 3 and 1 nM, respectively. It demonstrates 100-fold selectivity for TNKS1/2 over PARP1, PARP2, and PARP6 (IC50s = 2, 0.5, and >3 µM, respectively). By inhibiting TNKS1/2, AZ6120 has been shown to inhibit Wnt signaling in DLD-1 cells with an IC50...
| Keywords: | rel-2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimi... |
| Application: | TNKS1/2 inhibitor |
| CAS | 1645286-75-4 |
| MW: | 428.5 D |
From 52.00€
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