Description: ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 µM and >100 µM, respectively), ML-792 is an effective and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM,...

ML-792 is an inhibitor of SUMO-activating enzyme (SAE, IC50s = 0.003 and 0.011 µM with small ubiquitin-related modifier 1 (SUMO-1) or SUMO-2, respectively, as the ubiquitin-like proteins). It is selective for SAE over NEDD8-activating enzyme (NAE) and ubiquitin-activating enzyme (UAE, IC50s = 32 and >100 µM,...