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Item number: TGM-T4043-100mg

Description: ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor that inhibits beta-catenin reporter activity with an IC50 of 2.9 nM. Target: Wnt/beta-catenin, Porcupine. Smiles: Cn1c2ncn(CC(=O)Nc3ccc(nn3)-c3ccccc3)c2c(=O)n(C)c1=O. References: Madan B, et al. Wnt addiction of genetically defined...

Keywords:	ETC159, ETC-1922159, ETC 159
Application:	Porcupine (PORCN) inhibitor
CAS	1638250-96-0
MW:	391.38 D

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ETC-159

Item number: Cay24104-1

ETC-159 is a potent and orally bioavailable inhibitor of porcupine (PORCN, IC50s = 18.1 and 70 nM for mouse and Xenopus PORCN, respectively). It inhibits beta-catenin reporter activity (IC50 = 2.9 nM) and reduces the interaction of Wnt with its carrier protein WLS via decreased Wnt palmitoleation in STF3A cells, an...

Keywords:	ETC-1922159, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide
Application:	Porcupine (PORCN) inhibitor
CAS	1638250-96-0
MW:	391.4 D

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