Description: L-Cysteine S-sulfate (S-Sulfo-L-cysteine) is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for cystine lyase [1]. Target: NMDAR. Smiles: C([C@@H](C(O)=O)N)SS(=O)(=O)O. References: Steventon GB, et, al. Comparison of the sulfur-oxygenation...

S-Sulfocysteine is an NMDA receptor agonist. It is selective for the NMDA receptor over the AMPA receptor in radioligand binding assays (EC50s = 8.2 and 59 µM, respectively). S-Sulfocysteine (200 µM) is cytotoxic to primary mouse neuronal cells. It induces calcium influx and activates calpain-dependent degradation...