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Item number: TGM-T7534-100mg

Description: Teriflunomide (A 77-1726) is the principal active metabolite of leflunomide, an approved therapy for rheumatoid arthritis and multiple sclerosis. Target: Others. Smiles: C(F)(F)(F)C1=CC=C(NC(/C(=C(/C)\O)/C#N)=O)C=C1. References: Paul O , Oh . An update of teriflunomide for treatment of multiple...

Keywords:	A 77-1726
Application:	Targets dihydroorotate dehydrogenase [EC:1.3.5.2] (DHODH, pyrD)
CAS	163451-81-8
MW:	270.21 D

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A-771726

Item number: Cay14404-25

A-771726 is an active metabolite of the prodrug leflunomide (Cay-14860) that inhibits dihydroorotate dehydrogenase (DHODH, IC50 = 0.23 µM). A-771726 inhibits the production of prostaglandin E2 (PGE2, Cay-14010) in TNF-alpha- or IL-1alpha-stimulated isolated human synoviocytes (IC50s = 7 and 3 µM, respectively). It...

Keywords:	Flucyamide, HMR 1726, SU 20, Teriflunomide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2Z-butenamide
Application:	Dihydroorotate dehydrogenase inhibitor, tyrosine kinase inhibitor
CAS	163451-81-8
MW:	270.2 D

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