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FIIN-2
Item number: TGM-T6836-10mg
Description: FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively. Target: FGFR. Smiles: COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc2N(Cc2ccc(NC(=O)C=C)cc2)C1=O. References: Tan L, et al. Proc Natl Acad Sci U S A. 2014, 111(45),...
| Application: | FGFR inhibitor |
| CAS | 1633044-56-0 |
| MW: | 634.73 D |
From 35.00€
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FIIN-2
Item number: Cay19837-1
FIIN-2 is an irreversible FGFR inhibitor with IC50 values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1...
| Keywords: | N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)... |
| Application: | FGFR inhibitor |
| CAS | 1633044-56-0 |
| MW: | 634.7 D |
From 60.00€
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