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ARS-853
Item number: TGM-T7414-100mg
Description: ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 µM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells. Target: Apoptosis, Raf, Ras. Smiles: CC1(CC1)c1cc(NCC(=O)N2CCN(CC2)C2CN(C2)C(=O)C=C)c(O)cc1Cl. References: Lito P , Solomon M , Li L S , et al....
| Application: | KRAS-G12C inhibitor |
| CAS | 1629268-00-3 |
| MW: | 432.94 D |
From 152.00€
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ARS853
Item number: Cay19137-1
ARS853 is an inhibitor of K-RASG12C, a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells. ARS853 binds to the inactive GDP-bound state of K-RASG12C. It decreases the level of active GTP-bound K-RAS by 95% when used at a concentration of 10 µM in K-RASG12C mutant lung cancer...
| Keywords: | 1-[3-[4-[2-[[4-chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl]amino]acetyl]-1-piperazinyl]-1-azetidinyl]-2-propen-1-one |
| Application: | KRAS-G12C inhibitor |
| CAS | 1629268-00-3 |
| MW: | 432.9 D |
From 166.00€
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