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RAF709
Item number: TGM-T3711-100mg
Description: RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively. Target: Raf. Smiles: Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)N1CCOCC1. References: Robert AVERSA, et al. Biaryl amide compounds as kinase inhibitors. WO2014151616A1.
| Application: | B-RAF / C-RAF inhibitor |
| CAS | 1628838-42-5 |
| MW: | 542.55 D |
From 34.00€
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RAF709
Item number: Cay23820-1
RAF709 is a potent inhibitor of B-RAF and C-RAF (IC50s = 0.4 and 0.5 nM, respectively). It is selective for RAF kinases exhibiting >99% inhibition of only B-RAF, B-RAFV600E, and C-RAF in a panel of 456 kinases. However, DDR1, DDR2, FRK, and PDGFRbeta are also inhibited by >80% at a concentration of 1 µM. RAF709...
| Keywords: | N-[2-methyl-5'-(4-morpholinyl)-6'-[(tetrahydro-2H-pyran-4-yl)oxy][3,3'-bipyridin]-5-yl]-3-(trifluoromethyl)-benzamide |
| Application: | B-RAF / C-RAF inhibitor |
| CAS | 1628838-42-5 |
| MW: | 542.6 D |
From 61.00€
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