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Item number: TGM-TQ0058-100mg

Description: MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM). Target: Histone Methyltransferase, Epigenetic Reader Domain. Smiles: Cc1c(CN2CCC(CC2)Nc2ncnc3sc(CC(F)(F)F)cc23)ccc2[nH]c(cc12)C#N. References: Borkin D, et al. Pharmacologic inhibition of the Menin-MLL...

Application:	Menin-MLL fusion protein interaction inhibitor
CAS	1628317-18-9
MW:	484.54 D

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MI-463

Item number: Cay33525-1

MI-463 is an inhibitor of the protein-protein interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 15 nM). It inhibits growth of mouse bone marrow cells (BMCs) expressing the MLL fusion protein MLL-AF9 (GI50 = 0.23 µM), as well induces differentiation of MLL-AF9-transformed BMCs. MI-463...

Keywords:	4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile
Application:	Menin-MLL fusion protein interaction inhibitor
CAS	1628317-18-9
MW:	484.5 D

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