2 products were found matching "1628316-74-4"!
No results were found for the filter!
MI-136
Item number: TGM-T6889-100mg
Description: MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced. Target: Epigenetic Reader Domain, Androgen Receptor, Apoptosis. Smiles: FC(F)(F)Cc1cc2c(NC3CCN(Cc4ccc5[nH]c(cc5c4)C#N)CC3)ncnc2s1. References: Malik R, et al. Nat Med. 2015, 21(4):344-352.
| Application: | AR antagonist |
| CAS | 1628316-74-4 |
| MW: | 470.51 D |
From 40.00€
*
MI-136
Item number: Cay19245-1
MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM, Kd = 23.6 nM). By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling, inhibiting the growth of...
| Keywords: | 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile |
| Application: | AR antagonist |
| CAS | 1628316-74-4 |
| MW: | 470.5 D |
From 52.00€
*
