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Item number: TGM-T3552-100mg

Description: CPI-455 is a specific KDM5 inhibitor. Target: Histone Demethylase. Smiles: CC(C)c1c([nH]c2c(cnn2c1=O)C#N)-c1ccccc1. References: Vinogradova M, et al. Nat Chem Biol. 2016, 12(7):531-8.

Keywords:	CPI-455 HCl
Application:	KDM5A/B/C histone demethylase inhibitor
CAS	1628208-23-0
MW:	278.31 D

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CPI-455

Item number: Cay22127-1

CPI-455 is an inhibitor of the lysine demethylase 5 family (KDM5A-D). CPI-455 binds to the demethylase active site and selectively inhibits KDM5A-D (IC50s = 2-10 nM) over KDM2-4, 6, and 7 family members (IC50s = 1 to >25 µM). It increases histone H3K4me2/3 methylation in vitro and decreases the number of...

Keywords:	4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Application:	KDM5A/B/C histone demethylase inhibitor
CAS	1628208-23-0
MW:	278.3 D

From 35.00€ *

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