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Item number: TGM-T5491-100mg

Description: GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM. Target: c-RET. Smiles: CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1. References: Russell JP, et al. Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of...

Application:	RET inhibitor
CAS	1627856-64-7
MW:	467.41 D

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GSK3179106

Item number: Cay24023-1

GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC50 = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR, IC50 = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a...

Keywords:	4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-benzeneacetamide
Application:	RET inhibitor
CAS	1627856-64-7
MW:	467.4 D

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