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Item number: Cay15141-25

Roflumilast is an inhibitor of phosphodiesterase 4 (PDE4, IC50 = 0.8 nM). It is selective for PDE4 over PDE1, -2, -3, and -5 (IC50s = >10, >10, >10, and 8 µM, respectively). Roflumilast inhibits the production of leukotriene B4 (LTB4, Cay-20110) induced by fMLP (Cay-21495) in isolated human neutrophils with an IC50...

Keywords:	B 9302-107, BY 217, BYK 20869, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-benzamide
Application:	PDE4 inhibitor
CAS	162401-32-3
MW:	403.2 D

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