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Item number: TGM-T21747-100mg

Description: VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively. Target: GluR. Smiles: Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl. References: Cho HP, Garcia-Barrantes PM, Brogan JT, et al. Chemical modulation of...

CAS	1623101-11-0
MW:	446.67 D

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VU0483605

Item number: Cay16941-1

Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced...

Keywords:	3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide
Application:	Selective positive mGluR1 allosteric modulator
CAS	1623101-11-0
MW:	446.7 D

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