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Item number: TGM-TQ0037-100mg

Description: Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2). Target: JAK. Smiles: CCCS(=O)(=O)N[C@H]1C[C@H](C1)N(C)c1ncnc2[nH]ccc12. References: Vazquez ML, et al. Identification of...

Keywords:	PF-04965842
Application:	Targets Janus kinase 1 [EC:2.7.10.2] (JAK1)
CAS	1622902-68-4
MW:	323.41 D

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Abrocitinib

Item number: Cay34869-1

Abrocitinib is a JAK1 inhibitor (IC50 = 0.029 µM). It is selective for JAK1 over JAK2, JAK3, and TYK2 (IC50s = 0.803, >10, and 1.253 µM, respectively) and a panel of 40 kinases at 1 µM. Abrocitinib inhibits IFN-alpha-, IL-21-, or IL-27-induced phosphorylation of STAT3 (IC50s = 0.189, 0.511, and 0.271 µM,...

Keywords:	PF-04965842, N-[cis-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide
Application:	JAK1 inhibitor
CAS	1622902-68-4
MW:	323.4 D

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