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Item number: TGM-T6852-100mg

Description: GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death. Target: RIP kinase. Smiles: CN1c2ccccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O. References: Harris PA, et al. J Med Chem. 2016, 59(5):2163-2178.

Keywords:	GSK'481
Application:	RIP1 Ser166 phosphorylation inhibitor
CAS	1622849-58-4
MW:	377.39 D

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GSK481

Item number: Cay20308-1

GSK481 is an inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1 or RIPK1) that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM. It is selective for RIP1 over a panel of over 450 other kinases, including RIP3. GSK481 inhibits RIP1 from human and...

Keywords:	5-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-3-isoxazolecarboxamide
Application:	RIP1 Ser166 phosphorylation inhibitor
CAS	1622849-58-4
MW:	377.4 D

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