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Item number: TGM-T13153-100mg

Description: THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM). Target: CDK. Smiles: CN(C)CCCC(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1. References: Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul...

Application:	Non-cysteine reactive THZ1 derivative, Cdk7 inhibitor
CAS	1621523-07-6
MW:	568.07 D

From 380.00€ *

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THZ1-R

Item number: Cay31054-1

THZ1-R is a non-cysteine reactive derivative of the cyclin-dependent kinase 7 (Cdk7) inhibitor THZ1 (Cay-9002215). THZ1-R inhibits Cdk7 (IC50s = 142-241 nM) less potently than THZ1 and lacks antiproliferative activity against T cell acute lymphoblastic leukemia (T-ALL) cell lines.Formal Name:...

Keywords:	N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[4-(dimethylamino)-1-oxobutyl]amino]-benzamide
Application:	Non-cysteine reactive THZ1 derivative, Cdk7 inhibitor
CAS	1621523-07-6
MW:	568.1 D

442.00€ *

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