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LY2857785
LY2857785

Item number: TGM-TQ0060-100mg

Description: LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM). Target: CDK, Apoptosis. Smiles: CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)NC2CCOCC2)n1. References: Yin T, et al. A novel CDK9 inhibitor shows potent antitumor efficacy in...
Application: Cdk9 inhibitor
CAS 1619903-54-6
MW: 448.6 D
From 48.00€ *
Review
LY2857785
LY2857785

Item number: Cay34880-1

LY2857785 is an inhibitor of cyclin-dependent kinase 9 (Cdk9, IC50 = 0.011 µM). It also inhibits Cdk8 and Cdk7 (IC50s = 0.016 and 0.246 µM, respectively), as well as five kinases in a panel of 114 kinases (IC50s = 50 values of 0.22 and 0.197 µM, respectively. It inhibits phosphorylation of DNA-dependent RNA...
Keywords: trans-N1-[4-[2-methyl-3-(1-methylethyl)-2H-indazol-5-yl]-2-pyrimidinyl]-N4-(tetrahydro-2H-pyran-4-yl)-1,4-cyclohexanediamine
Application: Cdk9 inhibitor
CAS 1619903-54-6
MW: 448.6 D
From 35.00€ *
Review