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BAY 61-3606 HCl
Item number: TGM-T70377-10mg
Description: BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction,...
| Application: | Cell-permeable, reversible Syk inhibitor |
| CAS | 1615197-10-8 |
| MW: | 426.86 D |
From 142.00€
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BAY 61-3606 (hydrochloride)
Item number: Cay11423-1
BAY 61-3606 is an inhibitor of spleen tyrosine kinase (Syk, Ki = 7.5 nM). It is selective for Syk over Lyn, Fyn, Src, Itk, and BTK (Kis = >4.7 µM for all). BAY 61-3606 inhibits anti-IgE-induced histamine release in isolated human mast cells sensitized with IgE (IC50 = 5.1 nM), as well as reduces anti-IgM-induced...
| Keywords: | 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide, monohydrochloride |
| Application: | Cell-permeable, reversible Syk inhibitor |
| CAS | 1615197-10-8 |
| MW: | 426.9 D |
From 78.00€
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