Description: BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 µM and 2 µM). Target: Autophagy, FXR, GPCR19. Smiles: CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCO)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12. References: Festa C, et al. Exploitation of cholane scaffold for the discovery of potent and...

BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR, EC50s = 0.2 and 1 µM, respectively). It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter alpha (OSTalpha), and small heterodimer partner...