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Item number: TGM-T14687-100mg

Description: Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated...

Keywords:	BMS-986165
Application:	Targets non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] (TYK2)
CAS	1609392-27-9
MW:	425.46 D

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BMS 986165

Item number: Cay33524-1

BMS 986165 is an allosteric inhibitor of tyrosine kinase 2 (TYK2, IC50 = 0.2 nM for the recombinant TYK2 pseudokinase domain). It is selective for TYK2 over a panel of 249 protein and lipid kinases at 1 µM but does inhibit the JAK1 pseudokinase domain and bone morphogenetic protein receptor type II (BMPR2, IC50s = 1...

Keywords:	6-[(cyclopropylcarbonyl)amino]-4-[[2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino]-N-(methyl-d3)-3-pyridazinecar...
Application:	TYK2 allosteric inhibitor
CAS	1609392-27-9
MW:	425.5 D

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