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THZ2
Item number: TGM-T7296-100mg
Description: THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC). Target: CDK. Smiles: CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1. References: Huang JR, Qin WM, Wang K,et...
| Keywords: | CDK7-IN-1 |
| Application: | Cdk7 inhibitor |
| CAS | 1604810-84-5 |
| MW: | 566.05 D |
From 77.00€
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THZ2
Item number: Cay31055-10
THZ2 is a Cdk7 inhibitor (IC50 = 13.9 nM) and a derivative of THZ1 (Cay-9002215). It is selective for Cdk7 over Cdk1, -2, -5, -8, and -9 (IC50s = 96.9, 222, 134, 6,830, and 194 nM, respectively). THZ2 (0.001-1 nM) reduces proliferation of BT-549, HCC70, and MDA-MB-468 triple-negative breast cancer (TNBC) cells. In...
| Keywords: | N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-benzamide |
| Application: | Cdk7 inhibitor |
| CAS | 1604810-84-5 |
| MW: | 566.1 D |
From 85.00€
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