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THZ1
Item number: TGM-T3664-100mg
Description: THZ1 (CDK7 inhibitor) is a novel selective and potent covalent CDK7 inhibitor. Target: CDK. Smiles: CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1. References: Kwiatkowski N, et al. Nature. 2014, 511(7511):616-20.
| Keywords: | THZ1 2HCl, CDK7 inhibitor |
| Application: | CDK7 inhibitor |
| CAS | 1604810-83-4 |
| MW: | 566.05 D |
From 81.00€
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THZ1
Item number: Cay9002215-1
THZ1 is a Cdk7 inhibitor (IC50s = 3.2-15.6 nM in vitro) that selectively targets a remote cysteine residue located outside of the classic kinase domain. THZ1 also targets Cdk12 kinase activity although at a higher concentration (IC50 = 250 nM). It displays broad anti-proliferative activity against cancer cell lines,...
| Keywords: | N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-benzamide |
| Application: | CDK7 inhibitor |
| CAS | 1604810-83-4 |
| MW: | 566.1 D |
From 49.00€
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