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Dxd
Item number: Cay41699-10
Dxd is a derivative of the DNA topoisomerase I inhibitor exatecan (Cay-35452) and a starting material that has been used in the synthesis of antibody-drug conjugates (ADCs). It has been used in the synthesis of ADCs targeting HER2 with anticancer activity in vitro and in vivo.Formal Name:...
| Keywords: | N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indol... |
| Application: | Exatcan (DNA topoisomerase I inhibitor) derivative, ADC synthesis starting material |
| CAS | 1599440-33-1 |
| MW: | 493.5 D |
From 90.00€
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Dxd
Item number: TGM-T11249L-10mg
Description: Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 µM. It is used as a conjugated drug of HER2-targeting ADC. Target: ADC Cytotoxin, Topoisomerase. Smiles: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](NC(=O)CO)c(c3Cn1c2=O)c45. References: Ogitani Y, et al. DS-8201a,...
| Keywords: | Exatecan derivative for ADC, UNII-OQM5SD32BQ, OQM5SD32BQ |
| CAS | 1599440-33-1 |
| MW: | 493.48 D |
From 39.00€
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