Description: Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor with a b>K i of 59 nM. Bizine can modulate bulk histone methylation in cancer cells and has potential applications in neuroprotective [1]. Target: Others. Smiles: Cl.Cl.NNCCc1ccc(NC(=O)CCCc2ccccc2)cc1

Bizine is a phenelzine analog that inhibits lysine-specific demethylase 1 (LSD1, Ki(inact) = 59 nM). It is 23-fold, 63-fold, and >100-fold selective for LSD-1 over monoamine oxidase (MAO) A, MAOB, and LSD2, respectively. Bizine has been shown to induce bulk histone H3 lysine 4 dimethylation in LNCaP cancer cells...