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Item number: TGM-TQ0076-100mg

Description: KIRA6 is an effective inhibitor of IRE1alpha RNase kinase (IC50: 0.6 µM). It can trigger an apoptotic response. Target: IRE1. Smiles: CC(C)(C)c1nc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)c3ccccc23)c2c(N)nccn12. References: Mahameed M,et al. The unfolded protein response modulators GSK2606414 and KIRA6 are...

Application:	ATP-competitive IRE1alpha kinase inhibiting RNase attenuator
CAS	1589527-65-0
MW:	518.53 D

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KIRA6

Item number: Cay19151-1

The IRE1 pathway is a component of the unfolded protein response that senses unfolded proteins via an ER luminal domain that becomes oligomerized during stress. It is associated with promoting cell survival through the activity of the IRE1alpha RNase, whose activity upregulates proteins that enhance ER protein...

Keywords:	IRE1 Inhibitor IV, IRE1alpha Kinase Inhibiting RNase Attenuator 6,...
Application:	ATP-competitive IRE1alpha kinase inhibiting RNase attenuator
CAS	1589527-65-0
MW:	518.5 D

From 50.00€ *

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