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Item number: TGM-T4641-100mg

Description: Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. Target: Potassium Channel, Others, DNA/RNA Synthesis. Smiles: CC1(C)CC(CC(C)(C)N1)Oc1ccc(nn1)-c1ccc(cc1O)-c1cn[nH]c1. References: Palacino J, et al. SMN2 splice modulators enhance U1-pre-mRNA...

Keywords:	LMI 070, NVS-SM1
Application:	Targets survival motor neuron protein (SMN)
CAS	1562338-42-4
MW:	393.48 D

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LMI070

Item number: Cay26757-1

LMI070 is an SMN2 splice modulator. It selectively enhances SMN2 splicing by stabilizing the complex formed by the U1 small nuclear ribonucleic protein (snRNP) and SMN2 pre-mRNA. LMI070 (3-30 mg/kg) increases the expression of the full-length SMN2 trancript and, at doses ranging from 0.3 to 30 mg/kg, increases SMN...

Keywords:	Branaplam, NVS-SM1, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]-phenol
Application:	SMN2 splice modulator
CAS	1562338-42-4
MW:	393.5 D

From 61.00€ *

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