Description: BRD3308 is a highly selective inhibitor of HDAC3(IC50 of 54 nM), attenuating PE-mediated phosphorylation of ERK but not JNK. Target: Apoptosis, HDAC, HIV Protease. Smiles: CC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(F)cc1N. References: Lundh M, et al. Histone deacetylase 3 inhibition improves glycaemia and insulin...

BRD3308 is an inhibitor of histone deacetylase 3 (HDAC3, Ki = 29 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (Kis = 6,300 and 5,100 nM, respectively). BRD3308 (10 µM) reduces cytokine-induced increases in apoptosis in rat INS-1E beta cells. In vivo, BRD3308 (5 mg/kg) reduces plasma glucose levels in rats and...