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Item number: Cay17489-5

GSK 199 is an inhibitor of peptidyl arginine deiminase 4 (PAD4, IC50 = 200 nM in the absence of calcium). It selectively inhibits the production of citrulline by PAD4 over PAD1, PAD2, and PAD3 in kinetic assays. GSK 199 (10 µM) prevents histone H3 citrullination and neutrophil extracellular trap (NET) formation...

Keywords:	[(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone,...
Application:	Reversible PADI4 inhibitor
CAS	1549811-53-1
MW:	469 D

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