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Item number: TGM-T5420-100mg

Description: Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively). Target: Parasite, Drug Metabolite. Smiles:...

Keywords:	Chloroguanide Triazine
Application:	DHFR inhibitor
CAS	152-53-4
MW:	288.18 D

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Cycloguanil (hydrochloride)

Item number: Cay16861-10

Cycloguanil is the active metabolite of the antimalarial prodrug proguanil. Cycloguanil is formed from proguanil by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A in human liver microsomes. It is an inhibitor of dihydrofolate reductase (DHFR, Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes,...

Keywords:	Chloroguanide Triazine, NSC 3074, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine, monohydrochloride
Application:	DHFR inhibitor
CAS	152-53-4
MW:	288.2 D

From 43.00€ *

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