2 products were found matching "1508250-71-2"!

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Item number: TGM-T3506-100mg

Description: Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro. Target: EGFR. Smiles:...

Keywords:	EGF816, NVS-816
Application:	Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1)
CAS	1508250-71-2
MW:	495.02 D

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Nazartinib

Item number: Cay22409-1

Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs). It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC, IC50 = 4.18 nM), over cells expressing...

Keywords:	N-[7-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]hexahydro-1H-azepin-3-yl]-1H-benzimidazol-2-yl]-2-methyl-...
Application:	Mutant-selective EGFR inhibitor
CAS	1508250-71-2
MW:	495 D

From 50.00€ *

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