3 products were found matching "149709-62-6"!
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Sacubitril
Item number: TGM-T4574-100mg
Description: Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM and is a component of the heart failure medicine LCZ696. Target: Neprilysin. Smiles: CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O. References: Ksander GM,etal.Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.J...
| Keywords: | AHU-377, AHU377, AHU 377 |
| Application: | Targets neprilysin [EC:3.4.24.11] (MME, CD10) |
| CAS | 149709-62-6 |
| MW: | 411.49 D |
From 57.00€
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AHU-377 Tris Salt
Item number: LKT-A3080.1
LBQ657 prodrug, neprilysin inhibitor
| Keywords: | AHU377, Sacubitril |
| Application: | LBQ657 prodrug, neprilysin inhibitor |
| CAS | 149709-62-6 |
| MW: | 532.63 D |
From 219.00€
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AHU377
Item number: Cay36260-1
AHU377 is an ethyl ester prodrug from of the neprilysin inhibitor LBQ657 (Cay-19829). It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in...
| Keywords: | Sacubitril, (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid,... |
| Application: | LBQ657 (neprilysin inhibitor) prodrug form |
| CAS | 149709-62-6 |
| MW: | 411.5 D |
From 90.00€
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