3 products were found matching "1492952-76-7"!
No results were found for the filter!
Asciminib
Item number: LKT-A724091.1
Asciminib is an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both...
| Keywords: | ABL001, ABL-001, Asciminib free base,... |
| Application: | Allosteric ABL inhibitor, STAMP inhibitor |
| CAS | 1492952-76-7 |
| MW: | 449.84 D |
From 107.00€
*
Asciminib
Item number: TGM-T5177-100mg
Description: Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5-0.8nM). Target: Bcr-Abl. Smiles: C(NC1=CC=C(OC(Cl)(F)F)C=C1)(=O)C2=CC(=C(N=C2)N3CC[C@@H](O)C3)C=4C=CNN4. References: Wylie AA, et al. The allosteric inhibitor ABL2001 enables dual targeting of BCR-ABL1. Nature. 2017 Mar...
| Keywords: | ABL001 |
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 1492952-76-7 |
| MW: | 449.84 D |
From 57.00€
*
Asciminib
Item number: Cay26126-1
Asciminib is an allosteric inhibitor of Abl1 (IC50 = 0.45 nM). It is selective for Abl1 over a panel of more than 60 additional kinases (IC50s = >10 µM), as well as ion channels, nuclear receptors, G protein-coupled receptors (GPCRs), and transporters. Asciminib inhibits the proliferation of Luc-Ba/F3 cells...
| Keywords: | ABL001, N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(1H-pyrazol-3-yl)-3-pyridinecarboxamide |
| Application: | Allosteric Abl1 inhibitor |
| CAS | 1492952-76-7 |
| MW: | 449.8 D |
From 85.00€
*
