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Item number: TGM-T6919-100mg

Description: Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-kappaB signaling. Phase 2. Target: Nrf2, STING, Apoptosis, Others. Smiles:...

Keywords:	RTA-408
Application:	Targets nuclear factor erythroid 2-related factor 2 (NFE2L2, NRF2)
CAS	1474034-05-3
MW:	554.71 D

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RTA 408

Item number: Cay17854-1

RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations =25 nM. In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-gamma. At higher concentrations, RTA 408 inhibits tumor cell growth (GI50 =...

Keywords:	Omaveloxolone, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-propanamide
Application:	Nrf2 activator, Keap1 binding
CAS	1474034-05-3
MW:	554.7 D

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