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MI-2-2
Item number: TGM-T28036-1mg
Description: MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM. Target: Histone Methyltransferase. Smiles: C(C(F)(F)F)C1=CC2=C(N=CN=C2S1)N3CCN(CC3)C=4SC(C)(C)CN4. References: Shi A, et al. Structural insights into...
| Keywords: | MI22, MI 2 2 |
| Application: | Menin-MLL1 protein-protein interaction inhibitor |
| CAS | 1454920-20-7 |
| MW: | 415.5 D |
From 58.00€
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MI-2-2
Item number: Cay41109-1
MI-2-2 is an inhibitor of the protein-protein interaction between menin and mixed-lineage leukemia 1 (MLL1). It binds to menin (Kd = 22 nM) and inhibits the interaction between menin and MLL1 in a cell-free assay (IC50 = 46 nM). MI-2-2 reduces cell growth (GI50 = 3 µM) and induces cell cycle arrest at the G1 phase...
| Keywords: | 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)-thieno[2,3-d]pyrimidine |
| Application: | Menin-MLL1 protein-protein interaction inhibitor |
| CAS | 1454920-20-7 |
| MW: | 415.5 D |
From 67.00€
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