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Item number: Cay41841-1

ASP5878 is an inhibitor of wild-type FGFR1, -2, -3, and -4 (IC50s = 0.47, 0.6, 0.74, and 3.5 nM, respectively) and mutant FGFR3K650E, FGFR3K560M, and FGFR4N535K (IC50s = 1.6, 4.2, and 78 nM, respectively). It is selective for these FGFRs over a panel of 128 additional kinases at 200 nM but does inhibit VEGFR2 and...

Keywords:	4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]-2-pyrimidinyl]amino]-1H-pyrazole-1-ethanol
Application:	Wild-type/mutant FGFR inhibitor
CAS	1453208-66-6
MW:	407.4 D

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ASP5878

Item number: TGM-T5473-100mg

Description: ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L. Target: FGFR. Smiles: COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(CCO)c3)nc2)c1F. References: Futami T, et al. ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits...

Keywords:	ASP-5878
CAS	1453208-66-6
MW:	407.37 D

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